Effects of β-glucan Yeast Extract on Melanoma Progression, Tumor Infiltration, and Immune Modulation - Takeaways - MDSpire

Effects of β-glucan Yeast Extract on Melanoma Progression, Tumor Infiltration, and Immune Modulation

  • By

  • Bruno Miranda dos Santos Oliveira

  • Fernanda Paloma Duarte Trierweiler

  • Bianca Ramos Mesquita

  • Jose Nathan Andrade Muller Da Silva

  • Washington Luís dos Santos

  • José Mengel

  • Fabíola Cardillo

  • April 20, 2026

  • 0 min

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  • 1

    β-glucan yeast extract (β-GESc) shows potential as an immunomodulatory treatment for melanoma in a B16F10 mouse model.

  • 2

    Treatment with β-GESc increased spleen size and splenocyte counts, enhancing immune cell populations and MHC class II expression.

  • 3

    Treated mice exhibited improved survival rates, reduced tumor growth, and preserved spleen structure compared to untreated controls.

  • 4

    β-GESc treatment led to higher levels of CD4+ and CD8+ T cells producing IFN-γ and TNF-α, indicating robust immune activation.

  • 5

    The findings suggest that β-GESc may help overcome resistance in melanoma therapies, enhancing overall survival and immune response.

Original Source(s)

Effects of β-glucan Yeast Extract on Melanoma Progression, Tumor Infiltration, and Immune Modulation

  • by Bruno Miranda dos Santos Oliveira, Fernanda Paloma Duarte Trierweiler, Bianca Ramos Mesquita, Jose Nathan Andrade Muller Da Silva, Washington Luís dos Santos, José Mengel, Fabíola Cardillo

  • April 20, 2026

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