Dual inhibition of CSF-1R and IDO modulates the fibrotic and immunosuppressive tumor microenvironment in pancreatic ductal adenocarcinoma - Takeaways - MDSpire

Dual inhibition of CSF-1R and IDO modulates the fibrotic and immunosuppressive tumor microenvironment in pancreatic ductal adenocarcinoma

  • By

  • Lara C. Avsharian

  • Suvithanandhini Loganathan

  • Nancy D. Ebelt

  • Rebecca E. Ruggiero-Ruff

  • Sheyla Salcido

  • Skye E. Inal

  • Meera G. Nair

  • Edwin R. Manuel

  • July 15, 2026

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  • 1

    Pancreatic ductal adenocarcinoma (PDAC) is characterized by extensive fibrosis and an immunosuppressive tumor microenvironment that limits treatment efficacy.

  • 2

    Tumor-associated macrophages (TAMs) with a pro-tumor M2-like phenotype contribute to immune evasion and fibrosis in PDAC via TGF-β signaling and CSF-1R recruitment.

  • 3

    In high fibrotic KPC4662.5 tumors, dual targeting of CSF-1R and IDO significantly reduced tumor burden, while no advantage was seen in CSF1RLow tumors.

  • 4

    The combination therapy altered immune cell composition by decreasing PMN-MDSCs and increasing effector T cell subsets in the tumor microenvironment.

  • 5

    Fibrosis and CSF-1R expression may serve as potential biomarkers for response to combined CSF-1R and IDO inhibition in PDAC.

Original Source(s)

Dual inhibition of CSF-1R and IDO modulates the fibrotic and immunosuppressive tumor microenvironment in pancreatic ductal adenocarcinoma

  • by Lara C. Avsharian, Suvithanandhini Loganathan, Nancy D. Ebelt, Rebecca E. Ruggiero-Ruff, Sheyla Salcido, Skye E. Inal, Meera G. Nair, Edwin R. Manuel

  • July 15, 2026

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