The Role of IFI27 in Modulating Regulatory T Cell Activity Contributes to Lung Injury in Sepsis Through IL-10/STAT3 Pathway - Takeaways - MDSpire

The Role of IFI27 in Modulating Regulatory T Cell Activity Contributes to Lung Injury in Sepsis Through IL-10/STAT3 Pathway

  • By

  • Juan Li

  • Yingying Huang

  • Chaoping Ma

  • Guoxiang Liu

  • Caiting Chu

  • Jiameng Chen

  • Huiqi Wang

  • Jiawei Ye

  • Min Jiao

  • Yiran Guo

  • Jiyuan Zhang

  • Yuxin Leng

  • Chengjin Gao

  • April 22, 2026

  • 0 min

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  • 1

    IFI27 levels are positively correlated with sepsis severity in patients, indicating its potential as a prognostic marker.

  • 2

    Elevated IFI27 expression in septic mice leads to reduced Treg abundance and IL-10 secretion, worsening lung injury.

  • 3

    IFI27 inhibits STAT5 phosphorylation, which negatively impacts Treg function and promotes ferroptosis in lung epithelial cells.

  • 4

    The study demonstrates that IFI27 enhances lipid peroxidation by suppressing the IL-10/STAT3 signaling pathway in Tregs.

  • 5

    IFI27's role in modulating Treg activity highlights its significance in the immunopathogenesis of sepsis-induced lung injury.

Original Source(s)

The Role of IFI27 in Modulating Regulatory T Cell Activity Contributes to Lung Injury in Sepsis Through IL-10/STAT3 Pathway

  • by Juan Li, Yingying Huang, Chaoping Ma, Guoxiang Liu, Caiting Chu, Jiameng Chen, Huiqi Wang, Jiawei Ye, Min Jiao, Yiran Guo, Jiyuan Zhang, Yuxin Leng, Chengjin Gao

  • April 22, 2026

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