Negative impacts of ovarian endometrioma on preantral follicle development: implications for endometriosis-related infertility - Takeaways - MDSpire

Negative impacts of ovarian endometrioma on preantral follicle development: implications for endometriosis-related infertility

  • By

  • Makoto Orisaka

  • Aya Shirafuji

  • Natsumi Shimizu-Mizuno

  • Miki Uesaka

  • Yuko Fujita

  • Katsutoshi Mizuno

  • Masayuki Fujita

  • Yumiko Miyazaki

  • Toshimichi Onuma

  • Hideaki Tsuyoshi

  • Tetsuya Mizutani

  • Benjamin K. Tsang

  • Yoshio Yoshida

  • May 11, 2026

  • 0 min

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  • 1

    Endometriosis is a chronic inflammatory disorder and a major cause of female infertility, affecting 10-15% of women of reproductive age.

  • 2

    Ovarian endometriomas are linked to diminished ovarian function and directly impair follicular development, leading to infertility.

  • 3

    Endometrioma fluid (EmF) disrupts preantral follicle maturation by inducing oxidative stress and promoting fibrosis in ovarian cells.

  • 4

    EmF inhibits granulosa cell proliferation and estradiol production while promoting theca cell proliferation and fibrosis.

  • 5

    Therapeutic strategies targeting oxidative stress and fibrotic remodeling may be necessary to address endometrioma-associated infertility.

Original Source(s)

Negative impacts of ovarian endometrioma on preantral follicle development: implications for endometriosis-related infertility

  • by Makoto Orisaka, Aya Shirafuji, Natsumi Shimizu-Mizuno, Miki Uesaka, Yuko Fujita, Katsutoshi Mizuno, Masayuki Fujita, Yumiko Miyazaki, Toshimichi Onuma, Hideaki Tsuyoshi, Tetsuya Mizutani, Benjamin K. Tsang, Yoshio Yoshida

  • May 11, 2026

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