Gut barrier-microbiota crosstalk in sepsis: from pathogenesis to potential therapies - Takeaways - MDSpire

Gut barrier-microbiota crosstalk in sepsis: from pathogenesis to potential therapies

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Sepsis is a life-threatening condition with a mortality rate of 10-20%, increasing to 40-50% in cases of septic shock.
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The intestinal epithelial barrier (IEB) and gut microbiota play crucial roles in the pathogenesis and progression of sepsis.
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Dysbiosis and impaired IEB function can exacerbate inflammation and organ failure, worsening sepsis outcomes.
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Pathogen-associated and damage-associated molecular patterns disrupt immune homeostasis, driving systemic inflammation.
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Emerging therapeutic strategies for sepsis focus on restoring gut function to mitigate its impact on systemic inflammation.

Frontiers In Immunology

Frontiers In Immunology

Frontiers In Immunology

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