Gut barrier-microbiota crosstalk in sepsis: from pathogenesis to potential therapies - Takeaways - MDSpire
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Interactions Between Gut Barrier and Microbiota in Sepsis: Insights into Mechanisms and Therapeutic Approaches

  • By

  • Lingshuai Meng

  • Yingjie Liu

  • Nana Wang

  • Tiegang Li

  • Yu Wang

  • Mandi Li

  • June 18, 2026

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  • 1

    Sepsis is a life-threatening condition with a mortality rate of 10-20%, increasing to 40-50% in cases of septic shock.

  • 2

    The intestinal epithelial barrier (IEB) and gut microbiota play crucial roles in the pathogenesis and progression of sepsis.

  • 3

    Dysbiosis and impaired IEB function can exacerbate inflammation and organ failure, worsening sepsis outcomes.

  • 4

    Pathogen-associated and damage-associated molecular patterns disrupt immune homeostasis, driving systemic inflammation.

  • 5

    Emerging therapeutic strategies for sepsis focus on restoring gut function to mitigate its impact on systemic inflammation.

Original Source(s)

Gut barrier-microbiota crosstalk in sepsis: from pathogenesis to potential therapies

  • by Lingshuai Meng, Yingjie Liu, Nana Wang, Tiegang Li, Yu Wang, Mandi Li

  • June 18, 2026

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