What's Heart Disease Got to Do With It? - Takeaways - MDSpire

What's Heart Disease Got to Do With It?

Large meta-analysis explores how depression, anxiety, PTSD, and sleep disorders affect heart health

  • By

  • Henry Thomas

  • January 27, 2026

  • 3 min

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  • 1

    Mental health conditions like depression and PTSD are linked to a higher risk of acute coronary syndrome (ACS).

  • 2

    The systematic review included 25 studies with over 22 million participants examining mental disorders prior to cardiac events.

  • 3

    PTSD was associated with a 2.73 times higher risk of acute myocardial infarction (AMI), indicating moderate certainty.

  • 4

    Depressive and anxiety disorders were linked to 1.4 and 1.63 times the risk of ACS, respectively.

  • 5

    Integrating mental health management into cardiovascular care may improve outcomes, despite limitations in the evidence base.

Original Source(s)

What's Heart Disease Got to Do With It?

  • by Henry Thomas

  • January 27, 2026

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