From anxiety and depression to non-suicidal self-injury in youths: the mediating effect of neuroticism and the moderating effect of thyroid hormones - Takeaways - MDSpire
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The Role of Neuroticism and Thyroid Hormones in Linking Anxiety and Depression to Non-Suicidal Self-Injury in Adolescents

  • By

  • Hui Ma

  • Jing Zhang

  • Tiandao Wang

  • Fang Huang

  • Lei Li

  • July 3, 2026

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  • 1

    Neuroticism mediates the relationship between emotional symptoms and non-suicidal self-injury (NSSI) in adolescents.

  • 2

    Thyroid hormones TT3 and FT3 positively moderate the depression-NSSI relationship, while TSH negatively moderates it.

  • 3

    The negative moderating effect of TSH on the depression-NSSI link is significant in the high-neuroticism subgroup.

  • 4

    No significant moderating effects of thyroid hormones were found on the anxiety-NSSI pathway.

  • 5

    The study involved 104 Han Chinese adolescents and young adults aged 12-22 exhibiting NSSI behaviors.

Original Source(s)

From anxiety and depression to non-suicidal self-injury in youths: the mediating effect of neuroticism and the moderating effect of thyroid hormones

  • by Hui Ma, Jing Zhang, Tiandao Wang, Fang Huang, Lei Li

  • July 3, 2026

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