Glycocalyx Biomarkers as Early Predictors of Endotheliopathy in Pediatric and Young Adult Hematopoietic Stem Cell Transplantation Patients

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Glycocalyx biomarkers may predict endotheliopathy in pediatric and young adult patients post-hematopoietic stem cell transplantation.
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The study compared biomarker concentrations in HSCT patients with and without endotheliopathy at specific intervals.
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Syndecan-1 and Angiopoietin-2 levels differed significantly between endotheliopathy cases and controls at multiple time points.
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TIMP-1 and IGFBP-3 showed perfect predictive performance for endotheliopathy in the MDACC study.
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Further research is needed to confirm these findings due to the limited sample size and implications for generalizability.

Frontiers In Oncology

by Uchida, Kimberly , Mahadeo, Kris Michael, McArthur, Jennifer Ann, Avent, Yvonne , Hsu, Chia-Wei , Pan, Haitao , Elbahlawan, Lama , Hines, Melissa R, Sharma, Akshay , Tatevossian, Ruth G, Mahapatra, Sebabrata , Kumbaji, Meenasri , Sheikh, Irtiza , Li, Ying , Schadler, Keri , Ghafoor, Saad
April 13, 2026

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