Stem cell factor 248 shapes ILC2 transcriptional programs and promotes mucosal inflammation in allergic asthma - Takeaways - MDSpire
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Influence of Stem Cell Factor 248 on ILC2 Gene Expression and Its Role in Mucosal Inflammation Associated with Allergic Asthma

  • By

  • Nobuhiro Asai

  • Grace K. Lombardo

  • Ramon Ocadiz-Ruiz

  • Yao Gu

  • Andrew J. Rasky

  • Dana S. Garcia

  • Angela J. Montoya

  • Sarita Montaño

  • Kazuma Yagi

  • Wendy Fonseca

  • July 2, 2026

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  • 1

    Stem cell factor (SCF) is a cytokine that regulates cellular development and is involved in allergic inflammation through its isoform SCF248.

  • 2

    Group 2 innate lymphoid cells (ILC2s) are key mediators of type 2 airway inflammation and are increased in patients with asthma.

  • 3

    SCF248 expression is upregulated in the lungs and bone marrow during allergic inflammation, contributing to immune response regulation.

  • 4

    SCF deficiency in mice leads to reduced ILC2 populations and diminished type 2 cytokine production, indicating its role in allergic responses.

  • 5

    The study suggests SCF248 as a potential therapeutic target for mitigating ILC2-dependent pulmonary type 2 inflammatory responses.

Original Source(s)

Stem cell factor 248 shapes ILC2 transcriptional programs and promotes mucosal inflammation in allergic asthma

  • by Nobuhiro Asai, Grace K. Lombardo, Ramon Ocadiz-Ruiz, Yao Gu, Andrew J. Rasky, Dana S. Garcia, Angela J. Montoya, Sarita Montaño, Kazuma Yagi, Wendy Fonseca

  • July 2, 2026

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