Grape seed proanthocyanidins supplementation attenuates diquat-induced intestinal barrier damage in weaned pigs - Takeaways - MDSpire

Grape seed proanthocyanidins supplementation attenuates diquat-induced intestinal barrier damage in weaned pigs

  • By

  • Yiling Zhang

  • Xianghong He

  • Qian Zhao

  • Heping Li

  • Rui Qin

  • Weifang Zuo

  • Bo Han

  • May 7, 2026

  • 0 min

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  • 1

    Grape seed proanthocyanidins (GSP) reduce intestinal damage in weaned pigs exposed to diquat, a known oxidative stressor.

  • 2

    GSP supplementation significantly lowers serum urea levels and increases superoxide dismutase activity in diquat-challenged pigs.

  • 3

    GSP enhances intestinal morphology by increasing ileal villi height and improving villus-to-crypt ratios in affected pigs.

  • 4

    GSP modulates apoptosis-related proteins, down-regulating Caspases and up-regulating Claudin-1 and zonula occludens-1 in the intestine.

  • 5

    GSP supplementation boosts beneficial gut microbiota populations, including Lactobacillus and Bifidobacterium, in diquat-challenged pigs.

Original Source(s)

Grape seed proanthocyanidins supplementation attenuates diquat-induced intestinal barrier damage in weaned pigs

  • by Yiling Zhang, Xianghong He, Qian Zhao, Heping Li, Rui Qin, Weifang Zuo, Bo Han

  • May 7, 2026

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