Didymin mitigates neuroinflammation and preserves blood–brain barrier integrity after subarachnoid hemorrhage

1

Didymin treatment significantly improved neurological function scores in rats following subarachnoid hemorrhage (SAH).
2

Didymin reduced neuroinflammation by inhibiting microglial activation and pro-inflammatory cytokine expression after SAH.
3

Didymin preserved blood-brain barrier (BBB) integrity and alleviated brain edema by downregulating matrix metalloproteinase 9 (MMP9) expression.
4

In vitro, didymin suppressed MMP9 expression and promoted tight junction protein expression in human brain microvascular endothelial cells.
5

The study suggests didymin may be a potential therapeutic candidate for treating SAH due to its neuroprotective effects.

1