Case Report: KIF5B-ALK–rearranged renal cell carcinoma - Takeaways - MDSpire

Case Report: KIF5B-ALK–rearranged renal cell carcinoma

  • By

  • Jiaxi Yao

  • Zhifei Xie

  • Guangyao Shi

  • Ming Tan

  • Zhuo Liu

  • Min Lu

  • Hongxian Zhang

  • June 15, 2026

  • 0 min

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  • 1

    ALK-rearranged renal cell carcinoma (ALK-RCC) is a rare subtype of renal cancer characterized by ALK gene fusion with various partners.

  • 2

    The case study reports a 39-year-old man with ALK-RCC confirmed by next-generation sequencing revealing a KIF5B-ALK fusion.

  • 3

    Histopathological examination showed atypical morphology and renal epithelial differentiation in the tumor.

  • 4

    Managing ALK-RCC is challenging due to its rarity and limited treatment options, necessitating targeted therapies.

  • 5

    The findings enhance understanding of ALK-RCC, aiding clinicians and pathologists in diagnosis and treatment.

Original Source(s)

Case Report: KIF5B-ALK–rearranged renal cell carcinoma

  • by Jiaxi Yao, Zhifei Xie, Guangyao Shi, Ming Tan, Zhuo Liu, Min Lu, Hongxian Zhang

  • June 15, 2026

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