Beyond the coagulopathy phenotype in cancer-associated stroke: routine radiology report-based phenotyping and a practical diagnostic prioritization

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A study analyzed ischemic stroke patients with active malignancies, revealing 25.3% had multi-territory infarction.
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D-dimer levels were significantly higher in patients with multi-territory infarction compared to those with single-territory infarction.
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Each doubling of D-dimer was associated with a 62% increased likelihood of multi-territory infarction in active-cancer patients.
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The traditional coagulopathy phenotype only accounts for a limited proportion of strokes in patients with active malignancies.
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A phenotype-oriented diagnostic framework is recommended to improve stroke management in patients with cancer.

Frontiers In Neurology

by Shinsuke Muraoka, Kaito Kimura, Issei Takeuchi, Shunsaku Goto, Masahiro Nishihori, Takashi Izumi, Ryuta Saito
May 8, 2026

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