Immunological overlap stratification in anti-GBM disease: prognostic differences and serological correlations—a single-center retrospective cohort study - Takeaways - MDSpire

Immunological overlap stratification in anti-GBM disease: prognostic differences and serological correlations—a single-center retrospective cohort study

  • By

  • Yujun Qian

  • Yuyou Ye

  • Qian Zhou

  • Suyan Duan

  • Chengning Zhang

  • Yifei Ge

  • Yanggang Yuan

  • Changying Xing

  • Huijuan Mao

  • Bo Zhang

  • July 7, 2026

  • 0 min

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  • 1

    The study enrolled 67 patients with anti-GBM disease, stratifying them into three groups based on serological profiles.

  • 2

    The ANCA-anti-GBM double-positive group had the highest mean age at onset among the cohorts studied.

  • 3

    Significant differences in baseline anti-GBM antibody titers were observed across the three groups.

  • 4

    Early survival outcomes varied, with the ANCA-anti-GBM double-positive group showing the poorest early survival.

  • 5

    The study suggests that reliance solely on anti-GBM antibody titers for prognosis is inappropriate.

Original Source(s)

Immunological overlap stratification in anti-GBM disease: prognostic differences and serological correlations—a single-center retrospective cohort study

  • by Yujun Qian, Yuyou Ye, Qian Zhou, Suyan Duan, Chengning Zhang, Yifei Ge, Yanggang Yuan, Changying Xing, Huijuan Mao, Bo Zhang

  • July 7, 2026

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