Repeated aminoglycoside exposure activates interferon-stimulated genes in human renal proximal tubular models

1

Aminoglycosides are effective antibiotics but are associated with nephrotoxicity and ototoxicity, particularly neomycin and gentamicin.
2

Factors influencing aminoglycoside-induced nephrotoxicity include age, comorbidities, genetic predisposition, and drug type.
3

The study aimed to assess the transcriptional injury response of human proximal tubular cells to gentamicin and tobramycin.
4

Four human proximal tubular models were compared to determine their effectiveness in studying aminoglycoside nephrotoxicity.
5

Transcriptomics was utilized to identify gene expression changes related to aminoglycoside exposure before overt cytotoxicity occurs.

Archives Of Toxicology

by Vidya Chandrasekaran, Tamara Meijer, Martin O. Leonard, Anja Wilmes, Paul Jennings
July 14, 2026

1