CD19, immunoglobulin level, and varied anti-cytokine autoantibodies underline dichotomous susceptibility to types of infection in patients with thymomas - Takeaways - MDSpire

CD19, immunoglobulin level, and varied anti-cytokine autoantibodies underline dichotomous susceptibility to types of infection in patients with thymomas

  • By

  • Zhaohong Tan

  • Areum Shin

  • Rachel Ying Min Tan

  • Dongling Wang

  • Chiung-Hui Huang

  • Sharada Ravikumar

  • Liang En Wee

  • Yvonne Fu Zi Chan

  • Ying Ying Chua

  • Sen Hee Tay

  • Anindita Santosa

  • Gladys Gek Yen Tan

  • Doo Ri Kim

  • Hyun-Il Gil

  • Jae-Hoon Ko

  • Sun Hye Shin

  • Byung Woo Jhun

  • Siew Hoon Sim

  • Yae-Jean Kim

  • Louis Yi Ann Chai

  • July 10, 2026

  • 0 min

Share

  • 1

    Thymoma patients exhibit increased infection susceptibility, which is not solely attributed to Good syndrome with hypogammaglobulinemia.

  • 2

    Fifteen thymoma patients were categorized into two groups based on infection types: viral/Pneumocystis jirovecii and non-tuberculous mycobacterium/invasive infections.

  • 3

    The first group had low immunoglobulin levels and CD19+ B cells, while the second group had normal immunoglobulin levels and specific autoantibodies.

  • 4

    Autoantibodies against IL-12, IL-23, and IFN-α were found in patients with difficult-to-treat infections, affecting critical immune signaling pathways.

  • 5

    The study highlights distinct immune susceptibilities in thymoma patients, suggesting a need for tailored clinical management approaches.

Original Source(s)

CD19, immunoglobulin level, and varied anti-cytokine autoantibodies underline dichotomous susceptibility to types of infection in patients with thymomas

  • by Zhaohong Tan, Areum Shin, Rachel Ying Min Tan, Dongling Wang, Chiung-Hui Huang, Sharada Ravikumar, Liang En Wee, Yvonne Fu Zi Chan, Ying Ying Chua, Sen Hee Tay, Anindita Santosa, Gladys Gek Yen Tan, Doo Ri Kim, Hyun-Il Gil, Jae-Hoon Ko, Sun Hye Shin, Byung Woo Jhun, Siew Hoon Sim, Yae-Jean Kim, Louis Yi Ann Chai

  • July 10, 2026

Related Content

Survival beyond treatment: patterns and determinants of disease-free survival in cervical cancer at a tertiary care center in India

Context-dependent regulation of IL-6 in exercise and colorectal cancer cachexia

Case Report: Aplastic anemia associated with parvovirus B19 infection following neoadjuvant pembrolizumab-based chemoimmunotherapy for triple-negative breast cancer