Mechanisms underlying seizures and hypothermia during busulphan administration - Takeaways - MDSpire

Mechanisms underlying seizures and hypothermia during busulphan administration

  • By

  • Ibrahim El-Serafi

  • Sofia Berglund

  • Fadwa BenKessou

  • Alina Codita

  • Maryam Saghafian

  • David Lindskog

  • Matthijs C. Dorst

  • Gilad Silberberg

  • Manuchehr Abedi-Valugerdi

  • Wenyi Zheng

  • Rui He

  • Manon Renault

  • Weiying Zhou

  • Chao Yu

  • Massoud Vosough

  • Sandra Oerther

  • Ying Zhao

  • Jonas Mattsson

  • Moustapha Hassan

  • May 3, 2025

  • 0 min

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  • 1

    Busulphan is an alkylating agent used in high doses for conditioning prior to hematopoietic stem cell transplantation.

  • 2

    Busulphan is metabolized in the liver, primarily through conjugation with glutathione, producing several metabolites.

  • 3

    About 10% of patients receiving high doses of busulphan experience seizures, necessitating anticonvulsant prophylaxis.

  • 4

    Sulfolane, a busulphan metabolite, has been linked to neurotoxicity, including convulsions and hypothermia in animal studies.

  • 5

    The study investigates the pharmacokinetics of busulphan and its metabolites, focusing on their effects on behavior and neurotoxicity.

Original Source(s)

Mechanisms underlying seizures and hypothermia during busulphan administration

  • by Ibrahim El-Serafi, Sofia Berglund, Fadwa BenKessou, Alina Codita, Maryam Saghafian, David Lindskog, Matthijs C. Dorst, Gilad Silberberg, Manuchehr Abedi-Valugerdi, Wenyi Zheng, Rui He, Manon Renault, Weiying Zhou, Chao Yu, Massoud Vosough, Sandra Oerther, Ying Zhao, Jonas Mattsson, Moustapha Hassan

  • May 3, 2025

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