Transcriptomic differences in chromatin and cell cycle regulation in A549 cells after irradiation with carbon ions and X-rays - Takeaways - MDSpire

Transcriptomic differences in chromatin and cell cycle regulation in A549 cells after irradiation with carbon ions and X-rays

  • By

  • Hasan Nisar

  • Özdemirhan Serçin

  • Christine E. Hellweg

  • July 14, 2026

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  • 1

    High-LET carbon ion irradiation induces a distinct transcriptional response compared to low-LET X-rays in A549 non-small cell lung cancer cells.

  • 2

    Both radiation types activate a conserved DNA damage response, but carbon ions selectively suppress mitotic regulators.

  • 3

    Carbon ion exposure enriches inflammatory and stress-associated pathways, including TNF and NF-κB signaling.

  • 4

    High-LET irradiation downregulates core and linker histone genes, indicating chromatin regulatory reprogramming.

  • 5

    The study provides insights into LET-dependent radiobiology, highlighting differences in transcriptional programs between radiation types.

Original Source(s)

Transcriptomic differences in chromatin and cell cycle regulation in A549 cells after irradiation with carbon ions and X-rays

  • by Hasan Nisar, Özdemirhan Serçin, Christine E. Hellweg

  • July 14, 2026

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