Primary Undifferentiated Pleomorphic Sarcoma in the Stomach Resembling a Gastrointestinal Stromal Tumor: A Case Study and Review of Existing Literature - Takeaways - MDSpire

Primary Undifferentiated Pleomorphic Sarcoma in the Stomach Resembling a Gastrointestinal Stromal Tumor: A Case Study and Review of Existing Literature

  • By

  • Jun Mao

  • Xiaonan Yin

  • Zhaolun Cai

  • Chaoyong Shen

  • Bo Zhang

  • April 27, 2026

  • 0 min

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  • 1

    Undifferentiated pleomorphic sarcoma (UPS) is a rare and aggressive soft tissue sarcoma, with primary gastric cases being exceedingly uncommon.

  • 2

    A 71-year-old female was misdiagnosed with gastrointestinal stromal tumor (GIST) before undergoing R0 resection and splenectomy for a gastric mass.

  • 3

    Final diagnosis of primary gastric UPS was confirmed postoperatively through histopathological and molecular analyses, ruling out other tumors.

  • 4

    Despite adjuvant doxorubicin chemotherapy, the patient experienced tumor recurrence two months after surgery, indicating aggressive disease.

  • 5

    This case emphasizes the need for considering UPS in differential diagnoses of gastric masses and highlights the need for improved therapeutic strategies.

Original Source(s)

Primary Undifferentiated Pleomorphic Sarcoma in the Stomach Resembling a Gastrointestinal Stromal Tumor: A Case Study and Review of Existing Literature

  • by Jun Mao, Xiaonan Yin, Zhaolun Cai, Chaoyong Shen, Bo Zhang

  • April 27, 2026

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