Can Testosterone Affect Cognitive Function?

Systematic review finds modest, population-dependent effects on mood and cognition in adult men

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Testosterone therapy may provide modest benefits for mood and select cognitive outcomes in adult men, though effects are inconsistent.
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In men with treatment-resistant depression, testosterone therapy significantly reduced depressive symptoms compared to placebo.
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Cognitive improvements from testosterone therapy were domain specific, with benefits noted in verbal memory and visuospatial processing.
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Quality of life and sexual function improved consistently across studies, while anxiety outcomes were mixed.
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Testosterone therapy should be reserved for men with documented androgen deficiency and monitored under endocrinologic supervision.

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