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Can an antibody aid neuropsychiatric SLE diagnosis?

Investigators compared a candidate biomarker across three diagnostic groups.

  • By

  • Kathryn Wighton

  • August 27, 2026

  • 4 min

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  • 1

    Cerebrospinal fluid antisuprabasin antibody demonstrated greater diagnostic accuracy for neuropsychiatric systemic lupus erythematosus than other methods.

  • 2

    The study included 148 patients with systemic lupus erythematosus presenting with neuropsychiatric symptoms, evaluated at Renji Hospital in Shanghai.

  • 3

    CSF antisuprabasin antibody had 81% sensitivity and 74% specificity at an optimal cutoff of 76.36 ng/mL for identifying neuropsychiatric SLE.

  • 4

    A combined model of CSF antisuprabasin antibody, CSF white blood cell count, and serum antiribosomal P antibody yielded an area under the curve of 0.892.

  • 5

    The study's single-center design and limited cohort size may restrict the generalizability of the proposed diagnostic cutoff.

Original Source(s)

Can an antibody aid neuropsychiatric SLE diagnosis?

  • by Kathryn Wighton

  • August 27, 2026

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