Can an antibody aid neuropsychiatric SLE diagnosis?

Investigators compared a candidate biomarker across three diagnostic groups.

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Cerebrospinal fluid antisuprabasin antibody demonstrated greater diagnostic accuracy for neuropsychiatric systemic lupus erythematosus than other methods.
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The study included 148 patients with systemic lupus erythematosus presenting with neuropsychiatric symptoms, evaluated at Renji Hospital in Shanghai.
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CSF antisuprabasin antibody had 81% sensitivity and 74% specificity at an optimal cutoff of 76.36 ng/mL for identifying neuropsychiatric SLE.
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A combined model of CSF antisuprabasin antibody, CSF white blood cell count, and serum antiribosomal P antibody yielded an area under the curve of 0.892.
5

The study's single-center design and limited cohort size may restrict the generalizability of the proposed diagnostic cutoff.

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