Case Report: Latent autoimmune diabetes in two young female patients successfully treated with oral semaglutide and basal insulin - Takeaways - MDSpire

Case Report: Latent autoimmune diabetes in two young female patients successfully treated with oral semaglutide and basal insulin

  • By

  • Maria Elena Lunati

  • Giuseppe Galesi

  • Davide Bernasconi

  • Camilla Tinari

  • Paolo Fiorina

  • June 30, 2026

  • 0 min

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  • 1

    Latent autoimmune diabetes in youth (LADY) is characterized by autoimmune diabetes onset between ages 8 and 29, with slow progression to insulin dependence.

  • 2

    The case series discusses two young women with LADY who were treated successfully with oral semaglutide and basal insulin, achieving optimal glycemic control.

  • 3

    Case 1 involved a 20-year-old woman who lost 20 kg and achieved normal weight after 12 months of treatment with oral semaglutide and basal insulin.

  • 4

    Case 2 involved a 13-year-old girl who, after switching to oral semaglutide, showed optimal glycemic control and increased C-peptide levels after 15 months.

  • 5

    This case series is the first to demonstrate the efficacy of oral semaglutide in managing LADY, highlighting its potential benefits for weight control and liver health.

Original Source(s)

Case Report: Latent autoimmune diabetes in two young female patients successfully treated with oral semaglutide and basal insulin

  • by Maria Elena Lunati, Giuseppe Galesi, Davide Bernasconi, Camilla Tinari, Paolo Fiorina

  • June 30, 2026

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