AhR activation triggers the synergistic genotoxicity between benzo[a]pyrene and aflatoxin B1 in metabolic-competent HepaRP cells - Takeaways - MDSpire

AhR activation triggers the synergistic genotoxicity between benzo[a]pyrene and aflatoxin B1 in metabolic-competent HepaRP cells

  • By

  • Anis Messaoudi

  • Marie Garcia

  • Marc Audebert

  • Julien Vignard

  • Gladys Mirey

  • July 14, 2026

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  • 1

    Benzo[a]pyrene (BaP) is a Group 1 human carcinogen, primarily generated from incomplete combustion and high-temperature food processing.

  • 2

    Aflatoxin B1 (AFB1) is the most potent natural carcinogen, commonly contaminating staple foods, especially in tropical regions.

  • 3

    Dietary co-exposure to AFB1 and BaP may produce additive or synergistic toxic effects due to their similar genotoxic modes of action.

  • 4

    The BMC covariate approach allows for a more accurate assessment of combined effects and relative potencies of chemicals in mixtures.

  • 5

    The aryl hydrocarbon receptor (AhR) pathway may enhance AFB1 activation and genotoxicity through the upregulation of CYP enzymes by BaP.

Original Source(s)

AhR activation triggers the synergistic genotoxicity between benzo[a]pyrene and aflatoxin B1 in metabolic-competent HepaRP cells

  • by Anis Messaoudi, Marie Garcia, Marc Audebert, Julien Vignard, Gladys Mirey

  • July 14, 2026

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