Injectable Estradiol Use in Transgender and Gender-Diverse Individuals throughout the United States - Takeaways - MDSpire

Injectable Estradiol Use in Transgender and Gender-Diverse Individuals throughout the United States

  • By

  • Aaron L Misakian

  • Carly E Kelley

  • Erika A Sullivan

  • Julia J Chang

  • Gagandeep Singh

  • Sarah Kokosa

  • Jonathan Avila

  • Holly Cooper

  • Jane W Liang

  • Bren Botzheim

  • Meg Quint

  • Athavi Jeevananthan

  • Ellenor Chi

  • Madison Harmer

  • Laurel Hiatt

  • Michaela Kowalewski

  • Benjamin Steinberg

  • Telisha Tausinga

  • Hannah Tanner

  • Tiffany F Ho

  • Bayarmaa Mark

  • Brian Zenger

  • Sophia Hu

  • Amanuail Gebregzabheir

  • Justin M Penny

  • Danielle F Loeb

  • Tyler Strickland

  • Sean J Iwamoto

  • Micol S Rothman

  • Ole-Petter R Hamnvik

  • Danit Ariel

  • January 11, 2025

  • 0 min

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  • 1

    A study across 6 US medical centers assessed injectable estradiol dosing in transgender and gender-diverse adults designated male at birth.

  • 2

    The majority of patients reached supraphysiologic estradiol concentrations, indicating current dosing recommendations may be excessive.

  • 3

    Among patients injecting every 7 days, the median estradiol dose to achieve guideline-recommended levels was 4.0 mg.

  • 4

    Timing of the last estradiol injection significantly influenced serum estradiol concentrations in patients.

  • 5

    No significant differences were found in estradiol concentrations between intramuscular and subcutaneous routes of administration.

Original Source(s)

Injectable Estradiol Use in Transgender and Gender-Diverse Individuals throughout the United States

  • by Aaron L Misakian, Carly E Kelley, Erika A Sullivan, Julia J Chang, Gagandeep Singh, Sarah Kokosa, Jonathan Avila, Holly Cooper, Jane W Liang, Bren Botzheim, Meg Quint, Athavi Jeevananthan, Ellenor Chi, Madison Harmer, Laurel Hiatt, Michaela Kowalewski, Benjamin Steinberg, Telisha Tausinga, Hannah Tanner, Tiffany F Ho, Bayarmaa Mark, Brian Zenger, Sophia Hu, Amanuail Gebregzabheir, Justin M Penny, Danielle F Loeb, Tyler Strickland, Sean J Iwamoto, Micol S Rothman, Ole-Petter R Hamnvik, Danit Ariel

  • January 11, 2025

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