NAT10 as a central node in cancer biology: integrating epitranscriptomic regulation, metabolic reprogramming, and immune modulation - Takeaways - MDSpire

NAT10 as a central node in cancer biology: integrating epitranscriptomic regulation, metabolic reprogramming, and immune modulation

  • By

  • Wentao Bo

  • Ying Yi

  • Biao Zhao

  • Hang Dong

  • June 5, 2026

  • 0 min

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  • 1

    NAT10 is the sole known mRNA N4-acetylcytidine writer and plays a central role in cancer adaptation.

  • 2

    NAT10 integrates environmental stress signals with epitranscriptomic remodeling to support malignant progression.

  • 3

    Selective ac4C deposition by NAT10 enhances mRNA stability and amplifies oncogenic signaling networks.

  • 4

    NAT10 overexpression is linked to aggressive cancer phenotypes, including enhanced metastasis and therapeutic resistance.

  • 5

    Targeting NAT10 may provide strategies to overcome resistance to chemotherapy, targeted therapy, and immunotherapy.

Original Source(s)

NAT10 as a central node in cancer biology: integrating epitranscriptomic regulation, metabolic reprogramming, and immune modulation

  • by Wentao Bo, Ying Yi, Biao Zhao, Hang Dong

  • June 5, 2026

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