Lung ultrasound B-lines, NT-proBNP, and left atrial volume Index for bedside characterization of preserved-ejection-fraction phenotype in acute heart failure: a single-center observational study - Takeaways - MDSpire

Lung ultrasound B-lines, NT-proBNP, and left atrial volume Index for bedside characterization of preserved-ejection-fraction phenotype in acute heart failure: a single-center observational study

  • By

  • Bin Peng

  • Yanxia Zhang

  • June 5, 2026

  • 0 min

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  • 1

    The study evaluated lung ultrasound B-lines, NT-proBNP levels, and left atrial volume index for identifying HFpEF in acute heart failure patients.

  • 2

    Among 220 patients, 57 had HFpEF, and individual markers showed limited-to-moderate discriminatory ability for identifying this condition.

  • 3

    A three-marker model combining B-line score, NT-proBNP, and LAVI achieved an AUC of 0.737, indicating moderate ability to distinguish HFpEF.

  • 4

    The full exploratory model further increased the AUC to 0.765, suggesting improved identification of HFpEF with combined parameters.

  • 5

    The findings support using these markers as a bedside phenotype-characterization tool, rather than a definitive diagnostic model for HFpEF.

Original Source(s)

Lung ultrasound B-lines, NT-proBNP, and left atrial volume Index for bedside characterization of preserved-ejection-fraction phenotype in acute heart failure: a single-center observational study

  • by Bin Peng, Yanxia Zhang

  • June 5, 2026

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