Succinylation-annotated genes in AMI: multi-omics and single-cell prioritization of ASGR2 and NPL - Takeaways - MDSpire

Succinylation-annotated genes in AMI: multi-omics and single-cell prioritization of ASGR2 and NPL

  • By

  • Jie Yu

  • Xu Ma

  • Jing Fang

  • Yingying Liu

  • Cong Wang

  • Shuxia Shi

  • Kaile Wang

  • Yunlun Li

  • Lei Zhang

  • June 25, 2026

  • 0 min

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  • 1

    Eighteen succinylation-annotated genes related to acute myocardial infarction were identified through weighted gene co-expression network analysis.

  • 2

    ASGR2 and NPL were prioritized as exploratory candidate biomarkers based on differential expression and ROC analysis.

  • 3

    Classical monocytes were found to be more abundant in non-plaque rupture cases compared to plaque rupture cases.

  • 4

    ELISA results indicated elevated plasma levels of ASGR2 and NPL in acute myocardial infarction patients compared to controls.

  • 5

    The findings regarding ASGR2 and NPL remain exploratory and require independent prospective validation before clinical application.

Original Source(s)

Succinylation-annotated genes in AMI: multi-omics and single-cell prioritization of ASGR2 and NPL

  • by Jie Yu, Xu Ma, Jing Fang, Yingying Liu, Cong Wang, Shuxia Shi, Kaile Wang, Yunlun Li, Lei Zhang

  • June 25, 2026

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