Subclinical primary aldosteronism and major adverse cardiovascular events: evidence for a continuum of renin-independent aldosterone excess and a proposal for early detection - Takeaways - MDSpire

Subclinical primary aldosteronism and major adverse cardiovascular events: evidence for a continuum of renin-independent aldosterone excess and a proposal for early detection

  • By

  • Atef Akoum

  • Mounir Hakim

  • Rola Kwayess

  • Bahaa El Deen Wehbeh

  • Lina Alaaeddine

  • Mohamed Nasser El Shabrawi

  • Ashesh Das

  • Akshay Kumar

  • Sreekant Avula

  • Abdallah Rebeiz

  • Jason Li

  • June 23, 2026

  • 0 min

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  • 1

    Subclinical primary aldosteronism (sPA) exists on a continuum of renin-independent aldosterone excess, affecting even normotensive individuals.

  • 2

    Higher aldosterone levels with suppressed renin are linked to increased risks of hypertension, left ventricular hypertrophy, and cardiovascular events.

  • 3

    Overt primary aldosteronism (PA) shows significantly higher cardiovascular disease rates compared to essential hypertension, even when matched for blood pressure.

  • 4

    Emerging data suggest a graded cardiovascular risk associated with sPA that extends below traditional diagnostic thresholds for PA.

  • 5

    Current clinical practices underutilize PA screening, with less than 2% of eligible patients evaluated, potentially overlooking sPA and its cardiovascular risks.

Original Source(s)

Subclinical primary aldosteronism and major adverse cardiovascular events: evidence for a continuum of renin-independent aldosterone excess and a proposal for early detection

  • by Atef Akoum, Mounir Hakim, Rola Kwayess, Bahaa El Deen Wehbeh, Lina Alaaeddine, Mohamed Nasser El Shabrawi, Ashesh Das, Akshay Kumar, Sreekant Avula, Abdallah Rebeiz, Jason Li

  • June 23, 2026

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