Japanese Encephalitis Vaccine Decision Aid for Travelers: A Randomized Clinical Trial

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Japanese encephalitis (JE) has a fatality rate of 14% to 26% among symptomatic cases, with many survivors experiencing long-term neurologic issues.
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Two effective JE vaccines are available in Australia, but vaccination uptake among travelers remains low despite national guidelines recommending it.
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A web-based decision aid for JE vaccination, JEVaDA, was developed through a codesign process with travelers and clinicians to enhance decision-making.
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The randomized clinical trial evaluated JEVaDA's impact on informed decision-making and vaccine uptake compared to a standard government information resource.
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Primary outcomes included postintervention decisional conflict, while secondary outcomes assessed changes in JE knowledge, vaccination intention, and uptake.

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