Linking Autoimmune Disorders to Atrial Fibrillation: Insights from German Outpatient Data Analysis

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Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, increasing risks of stroke, heart failure, and mortality.
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Autoimmune diseases (AIDs) show a significant association with AF, with a nationwide Danish study reporting a 1.63 hazard ratio for AF incidence.
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This study utilized a large German outpatient database to analyze the link between AIDs and newly diagnosed AF, addressing gaps in previous research.
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The analysis included various AIDs and matched patients based on cardiovascular comorbidities and medications to ensure accurate results.
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Sex-stratified analyses were conducted to explore differences in AF risk between women and men, acknowledging variations in immune regulation.

Bmc Cardiovascular Disorders

by Jamschid Sedighi, Mark Luedde, Priyanka Boettger, Boris Dinov, Birgit Assmus, Samuel Sossalla, Karel Kostev
February 2, 2026

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