Maternal Hyperoxygenation for Prenatal Risk Stratification of Pulmonary Venous Obstruction in Total Anomalous Pulmonary Venous Return - Takeaways - MDSpire
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Prenatal Risk Assessment of Pulmonary Venous Obstruction in Total Anomalous Pulmonary Venous Return through Maternal Hyperoxygenation

  • By

  • Michelle Mathevosian

  • Shuo Wang

  • Arpine Davtyan

  • Jon Detterich

  • Jodie Votava-Smith

  • Jay Pruetz

  • September 5, 2026

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  • 1

    Total anomalous pulmonary venous return (TAPVR) is a rare congenital heart defect characterized by abnormal pulmonary vein drainage.

  • 2

    Pulmonary venous obstruction (PVO) occurs in 25–50% of TAPVR cases and significantly impacts neonatal morbidity and mortality.

  • 3

    Maternal hyperoxygenation (MHO) enhances fetal pulmonary blood flow and may reveal previously undetected anatomical obstructions.

  • 4

    MHO testing was conducted on three fetuses with TAPVR, correlating Doppler measurements with neonatal clinical outcomes.

  • 5

    Case findings indicated that MHO can provide critical insights for perinatal planning and potential postnatal interventions.

Original Source(s)

Maternal Hyperoxygenation for Prenatal Risk Stratification of Pulmonary Venous Obstruction in Total Anomalous Pulmonary Venous Return

  • by Michelle Mathevosian, Shuo Wang, Arpine Davtyan, Jon Detterich, Jodie Votava-Smith, Jay Pruetz

  • September 5, 2026

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