Inverse Relationship Between Serum Small Dense LDL Cholesterol Levels and Kidney Stone Incidence: Findings from Two Distinct Cross-Sectional Studies - Takeaways - MDSpire

Inverse Relationship Between Serum Small Dense LDL Cholesterol Levels and Kidney Stone Incidence: Findings from Two Distinct Cross-Sectional Studies

  • By

  • Yangyang Zhang

  • Haibo Qin

  • Junping Yang

  • Xudong Shen

  • Zongyao Hao

  • Chaozhao Liang

  • April 29, 2026

  • 0 min

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  • 1

    Higher serum small dense LDL cholesterol (sdLDL-C) levels are associated with a lower risk of kidney stones in adults.

  • 2

    The study analyzed data from 757 participants in China and 9,721 adults from NHANES to evaluate the sdLDL-C and kidney stone relationship.

  • 3

    In the Chinese cohort, the odds ratio for lower kidney stone risk with higher sdLDL-C was 0.53, indicating a significant protective effect.

  • 4

    The NHANES cohort showed a similar negative association, with an odds ratio of 0.68 for kidney stones and sdLDL-C levels.

  • 5

    Subgroup analyses revealed that the protective effect of sdLDL-C was more pronounced in individuals over 40 years in China and younger females in NHANES.

Original Source(s)

Inverse Relationship Between Serum Small Dense LDL Cholesterol Levels and Kidney Stone Incidence: Findings from Two Distinct Cross-Sectional Studies

  • by Yangyang Zhang, Haibo Qin, Junping Yang, Xudong Shen, Zongyao Hao, Chaozhao Liang

  • April 29, 2026

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