Differentiation defects reposition sebaceous glands as inflammatory instigators in the early pathogenesis of hidradenitis suppurativa - Takeaways - MDSpire

Differentiation defects reposition sebaceous glands as inflammatory instigators in the early pathogenesis of hidradenitis suppurativa

  • By

  • Xiang Chen

  • Jiaqi Li

  • Yibo Feng

  • Zhanyan Pan

  • Qiong Wu

  • Xinyi Xu

  • Qian Zhao

  • Tingting Hu

  • Guangjie Chen

  • Christos C. Zouboulis

  • Xiaohui Mo

  • Qiang Ju

  • June 8, 2026

  • 0 min

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  • 1

    Sebaceous gland size is significantly reduced in both non-lesional and early lesional skin of hidradenitis suppurativa patients compared to healthy controls.

  • 2

    Aberrant stem cell commitment and downregulation of tight junction signaling were observed in sebaceous glands from hidradenitis suppurativa patients.

  • 3

    CLDN1 knockdown in sebocytes induced a pro-inflammatory response and a shift toward keratinocyte-like differentiation.

  • 4

    Lysophosphatidylcholine overproduction was linked to metabolic reprogramming in sebocytes, promoting keratinocyte proliferation and inflammation.

  • 5

    Sebaceous gland dysfunction and tight junction disruption are proposed as primary events in the early pathogenesis of hidradenitis suppurativa.

Original Source(s)

Differentiation defects reposition sebaceous glands as inflammatory instigators in the early pathogenesis of hidradenitis suppurativa

  • by Xiang Chen, Jiaqi Li, Yibo Feng, Zhanyan Pan, Qiong Wu, Xinyi Xu, Qian Zhao, Tingting Hu, Guangjie Chen, Christos C. Zouboulis, Xiaohui Mo, Qiang Ju

  • June 8, 2026

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