Antibody Oxidation’s Hidden Handedness Comes Into View - Takeaways - MDSpire

Antibody Oxidation’s Hidden Handedness Comes Into View

Integrated NMR and LC-MS analysis distinguishes elusive stereochemical forms of methionine oxidation in IgG1 Fc regions, offering a sharper tool for biologic drug quality control

  • April 8, 2026

  • 2 min

Share

  • 1

    A new analytical strategy reveals subtle antibody damage from methionine oxidation in therapeutic antibodies.

  • 2

    Researchers distinguished R and S stereoisomers of methionine sulfoxide in IgG1 antibodies using advanced techniques.

  • 3

    The study focused on Met252 and Met428, whose oxidation affects antibody stability and receptor interactions.

  • 4

    NMR and LC-MS confirmed the identities and abundances of oxidized methionine species in antibodies.

  • 5

    The findings could enhance stability testing and manufacturing control for antibody therapeutics.

Original Source(s)

Antibody Oxidation’s Hidden Handedness Comes Into View

  • April 8, 2026

Related Content

Bilateral ovarian masses, massive ascites, and prior appendectomy: must it be ovarian cancer? ——a case report of pseudomyxoma peritonei 24 years after appendectomy

Ethical considerations and management strategies for fertility preservation in women of reproductive age with malignant tumors: Chinese practices and perspectives

Editorial: Discovery of small molecule lead compounds: a driving force to unravel new anti-cancer targets and mechanisms, volume III