Regulatory T cell dysfunction and exhaustion in uveitis: immunometabolic mechanisms, microenvironmental drivers, and emerging therapeutic strategies - Takeaways - MDSpire

Regulatory T cell dysfunction and exhaustion in uveitis: immunometabolic mechanisms, microenvironmental drivers, and emerging therapeutic strategies

  • By

  • Xingyu Su

  • Qiuyu Tan

  • Liu Zheng

  • Zhixiang Ding

  • May 5, 2026

  • 0 min

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  • 1

    Non-infectious uveitis is a major cause of blindness, affecting working-age individuals and imposing significant socio-economic burdens.

  • 2

    Regulatory T cells (Tregs) are essential for maintaining ocular homeostasis, but their dysfunction contributes to persistent inflammation in uveitis.

  • 3

    Distinct uveitis subtypes exhibit unique patterns of Treg reduction and exhaustion, impacting personalized therapeutic approaches.

  • 4

    Molecular mechanisms of Treg dysfunction include altered surface molecule expression and metabolic dysregulation, influencing disease pathogenesis.

  • 5

    Therapeutic strategies to restore Treg function include low-dose interleukin-2 therapy and immune checkpoint modulation.

Original Source(s)

Regulatory T cell dysfunction and exhaustion in uveitis: immunometabolic mechanisms, microenvironmental drivers, and emerging therapeutic strategies

  • by Xingyu Su, Qiuyu Tan, Liu Zheng, Zhixiang Ding

  • May 5, 2026

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