Single-cell RNA sequencing reveals microglial proliferative bias and neuroinflammatory communication reprogramming following traumatic brain injury - Takeaways - MDSpire

Single-cell RNA sequencing reveals microglial proliferative bias and neuroinflammatory communication reprogramming following traumatic brain injury

  • By

  • Xue Zhang

  • Na Sun

  • Manman Zhu

  • Yan Huang

  • July 10, 2026

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  • 1

    Single-cell RNA sequencing identified 14 distinct cell groups in a mouse model of moderate traumatic brain injury.

  • 2

    Seven microglial subclusters were identified, showing significant remodeling after traumatic brain injury.

  • 3

    Homeostatic microglial subclusters decreased, while disease-associated and proliferating subclusters increased post-TBI.

  • 4

    Microglial transition from homeostatic to pro-inflammatory states was confirmed by pseudotime trajectory analysis.

  • 5

    Intercellular communication analysis revealed enhanced signaling pathways promoting M1 polarization and neuroinflammation.

Original Source(s)

Single-cell RNA sequencing reveals microglial proliferative bias and neuroinflammatory communication reprogramming following traumatic brain injury

  • by Xue Zhang, Na Sun, Manman Zhu, Yan Huang

  • July 10, 2026

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