Research on the severity of symptoms in children with ASD based on integrated machine learning and structural equation modeling: age-specific predictive features and mediation effect path analysis - Takeaways - MDSpire
Coming Soon: Introducing MDSpire News. Learn more
Conexiant’s news site is now MDSpire News. Learn more

Investigation of Symptom Severity in Pediatric ASD Using Integrated Machine Learning and Structural Equation Modeling: Age-Dependent Predictive Factors and Mediation Pathway Analysis

  • By

  • Shimei Lu

  • Liangqiong Deng

  • Daoqing Gong

  • Xinyi Jia

  • Xiya Lang

  • Lianghui Diao

  • Liqin Ma

  • Pingjing Wen

  • June 17, 2026

Share

  • 1

    The study recruited 608 children with ASD, stratifying them into low-age and high-age groups for analysis.

  • 2

    Machine learning identified language as the core predictive feature for the low-age group, while personal-social and motor skills were more significant in the high-age group.

  • 3

    Structural equation modeling revealed a masking effect of age at first diagnosis on symptom severity, with a non-significant total effect.

  • 4

    Developmental level significantly mediated the relationship between age at first diagnosis and symptom severity, especially in the low-age group.

  • 5

    Findings suggest age-stratified interventions may improve clinical management of ASD by addressing specific developmental and physical factors.

Original Source(s)

Research on the severity of symptoms in children with ASD based on integrated machine learning and structural equation modeling: age-specific predictive features and mediation effect path analysis

  • by Shimei Lu, Liangqiong Deng, Daoqing Gong, Xinyi Jia, Xiya Lang, Lianghui Diao, Liqin Ma, Pingjing Wen

  • June 17, 2026

Related Content

Autism Announcement Changes Search Behavior

Online interest in leucovorin, folate products, and acetaminophen-related autism concerns increased markedly in the 2 weeks following the White House announcement.

Genetic insights into autism spectrum disorder with intellectual disability: a regional population-based study from Northwest China

Beta-2 Agonists Tied to ASD Risk?

Systematic review of 8 observational studies found limited evidence on associations between prenatal asthma-medication exposure and neurodevelopmental outcomes, with autism spectrum disorder the only outcome suitable for meta-analysis.