Effects of transcutaneous auricular vagus nerve stimulation on patients with post-stroke insomnia: a randomized controlled trial protocol - Takeaways - MDSpire

Effects of transcutaneous auricular vagus nerve stimulation on patients with post-stroke insomnia: a randomized controlled trial protocol

  • By

  • Jifei Sun

  • Siyan Chen

  • Chenjie Ma

  • Hongwei Liu

  • Yuan Zhou

  • Haoran Gao

  • Kexin Ma

  • Xiaojian Zhang

  • Xue Xiao

  • June 29, 2026

  • 0 min

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  • 1

    Post-stroke insomnia (PSI) affects over 50% of stroke survivors and is linked to increased risk of stroke recurrence and anxiety disorders.

  • 2

    Current treatments for PSI, including sedative-hypnotics and cognitive behavioral therapy, face limitations such as tolerance, dependence, and poor adherence.

  • 3

    Transcutaneous auricular vagus nerve stimulation (taVNS) is a non-invasive technique showing potential in treating insomnia and post-stroke depression.

  • 4

    This study will enroll 48 PSI patients in a randomized controlled trial to evaluate the efficacy of taVNS compared to a sham intervention.

  • 5

    Primary outcomes will include multimodal MRI indicators and clinical efficacy scales assessed at baseline, week 2, and week 4.

Original Source(s)

Effects of transcutaneous auricular vagus nerve stimulation on patients with post-stroke insomnia: a randomized controlled trial protocol

  • by Jifei Sun, Siyan Chen, Chenjie Ma, Hongwei Liu, Yuan Zhou, Haoran Gao, Kexin Ma, Xiaojian Zhang, Xue Xiao

  • June 29, 2026

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