CLDN18.2 May Define Lung Adenocarcinoma Phenotype - Takeaways - MDSpire

CLDN18.2 May Define Lung Adenocarcinoma Phenotype

Frequent CLDN18.2 expression was associated with gastric-type differentiation and reduced spread through air spaces in pulmonary invasive mucinous adenocarcinoma.

  • By

  • Andrea Surnit

  • July 22, 2026

  • 3 min

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  • 1

    CLDN18.2 was expressed in 61% of pulmonary invasive mucinous adenocarcinomas, with high expression in 36% of tumors.

  • 2

    The study evaluated 117 tumors from patients who underwent curative-intent surgical resection between 2018 and 2020.

  • 3

    CLDN18.2 expression correlated with gastric-type mucin differentiation, with 90% of CLDN18.2-positive tumors expressing MUC5AC.

  • 4

    The study found no significant association between CLDN18.2 or MUC5AC expression and overall survival.

  • 5

    The authors noted limitations including a small cohort and called for multicenter prospective studies to explore CLDN18.2's therapeutic relevance.

Original Source(s)

CLDN18.2 May Define Lung Adenocarcinoma Phenotype

  • by Andrea Surnit

  • July 22, 2026

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