ADGRD1 promotes bladder cancer progression and angiogenesis via the PI3K/AKT/mTOR-mediated pro-angiogenic secretome - Takeaways - MDSpire

ADGRD1 promotes bladder cancer progression and angiogenesis via the PI3K/AKT/mTOR-mediated pro-angiogenic secretome

  • By

  • Chen Li

  • Zhichao Yang

  • Jialei Zhang

  • Xiaodong Yan

  • Hongwei Su

  • May 28, 2026

  • 0 min

Share

  • 1

    ADGRD1 is significantly enriched in advanced-stage and high-grade bladder cancer, serving as a predictor of poor survival outcomes.

  • 2

    Functional assays indicate that ADGRD1 promotes bladder cancer cell proliferation, migration, invasion, and angiogenesis.

  • 3

    ADGRD1 enhances endothelial tube formation by upregulating a secretome rich in VEGF, PDGF, and IL-8.

  • 4

    ADGRD1 activates the PI3K/AKT/mTOR signaling pathway, evidenced by increased phosphorylation of its components.

  • 5

    Pharmacological inhibition of the PI3K/AKT/mTOR pathway reverses the oncogenic and pro-angiogenic effects of ADGRD1.

Original Source(s)

ADGRD1 promotes bladder cancer progression and angiogenesis via the PI3K/AKT/mTOR-mediated pro-angiogenic secretome

  • by Chen Li, Zhichao Yang, Jialei Zhang, Xiaodong Yan, Hongwei Su

  • May 28, 2026

Related Content

Real-world healthcare resource use and costs associated with the management of locally advanced head and neck cancer in Portugal – TRACE2 study

A review of epidermal growth factor receptor ligands in glucose homeostasis

Diffuse large B-cell lymphoma presenting as a scalp tumor with skull destruction and neurological symptoms: a case report