Single-cell sequencing uncovers clonal dynamics profiles and therapeutic resistance biomarkers in relapsed and refractory peripheral T-cell lymphoma - Takeaways - MDSpire

Single-cell sequencing uncovers clonal dynamics profiles and therapeutic resistance biomarkers in relapsed and refractory peripheral T-cell lymphoma

  • By

  • Ning Zhang

  • Jingwei Yu

  • Hengqi Liu

  • Zechao Hu

  • Shen Meng

  • Cong Sun

  • Yaxiao Lu

  • Xia Liu

  • Zheng Song

  • Lanfang Li

  • Lihua Qiu

  • Zhengzi Qian

  • Bin Meng

  • Wenchen Gong

  • Shiyong Zhou

  • Xianhuo Wang

  • Huilai Zhang

  • July 10, 2026

  • 0 min

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  • 1

    Peripheral T-cell lymphoma (PTCL) is a heterogeneous and aggressive subtype of non-Hodgkin lymphoma, with 30% of patients developing relapsed or refractory disease.

  • 2

    Single-cell RNA sequencing was utilized to analyze tumor samples from six patients with relapsed and refractory PTCL, revealing transcriptional profiles of malignant T-cell clones.

  • 3

    Significant upregulation of genes linked to cell proliferation and immune modulation was observed in relapsed and refractory PTCL, indicating potential mechanisms of treatment resistance.

  • 4

    Specific protumorigenic ligand-receptor interactions were identified in the tumor microenvironment, which may facilitate immune evasion by malignant T cells.

  • 5

    The study highlights the transcriptional heterogeneity of malignant T-cell clones in relapsed and refractory PTCL, suggesting implications for therapeutic strategies.

Original Source(s)

Single-cell sequencing uncovers clonal dynamics profiles and therapeutic resistance biomarkers in relapsed and refractory peripheral T-cell lymphoma

  • by Ning Zhang, Jingwei Yu, Hengqi Liu, Zechao Hu, Shen Meng, Cong Sun, Yaxiao Lu, Xia Liu, Zheng Song, Lanfang Li, Lihua Qiu, Zhengzi Qian, Bin Meng, Wenchen Gong, Shiyong Zhou, Xianhuo Wang, Huilai Zhang

  • July 10, 2026

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