Metastatic progression and treatment challenges in EBV-associated pulmonary lymphoepithelioma-like carcinoma: a case report - Takeaways - MDSpire

Metastatic progression and treatment challenges in EBV-associated pulmonary lymphoepithelioma-like carcinoma: a case report

  • By

  • Min Wei

  • Sumin Wu

  • Yanbo Wang

  • Mengyuan Zhu

  • Xiaofen Pan

  • Chengming Ke

  • June 23, 2026

  • 0 min

Share

  • 1

    The case study presents a 42-year-old female with EBV-related pulmonary lymphoepithelioma-like carcinoma (LELC) initially diagnosed at stage IIIB.

  • 2

    After radical surgery and adjuvant chemoradiotherapy, the patient developed cervical lymph node metastasis, advancing to stage IV disease with liver involvement.

  • 3

    First-line therapy with pembrolizumab and chemotherapy led to an initial partial response, but persistent high-grade fever complicated ongoing treatment.

  • 4

    Serial plasma EBV-DNA levels correlated with disease activity, decreasing during treatment response and increasing with disease progression.

  • 5

    The case highlights the aggressive nature of metastatic pulmonary LELC and the challenges posed by atypical tumor-associated fever on treatment continuity.

Original Source(s)

Metastatic progression and treatment challenges in EBV-associated pulmonary lymphoepithelioma-like carcinoma: a case report

  • by Min Wei, Sumin Wu, Yanbo Wang, Mengyuan Zhu, Xiaofen Pan, Chengming Ke

  • June 23, 2026

Related Content

Blood-based DNA methylation marker model for short-term and long-term lung cancer risk prediction

Case Report: Neoadjuvant chemoimmunotherapy achieving pathological complete response in two cases of stage III EGFR-mutant NSCLC with high PD-L1 expression

Multidisciplinary treatment of follicular thyroid carcinoma with hepatic and pulmonary metastases: a case report and literature review