Non-anticoagulant heparins: glycan-mediated immune modulation and therapeutic applications - Takeaways - MDSpire

Heparins Without Anticoagulant Properties: Immune Modulation via Glycan Interactions and Clinical Uses

  • By

  • Yaner Gu

  • Qiong Wang

  • Juan Fang

  • Jing Chen

  • Kaiting Hong

  • Zhanwei Zhang

  • Syed Shams Ul Hassan

  • Yin Chen

  • Xuqian Zhang

  • July 21, 2026

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  • 1

    Non-anticoagulant heparins (NAHs) are modified heparin derivatives that retain biological activities while lacking anticoagulant effects.

  • 2

    NAHs exhibit therapeutic potential in inflammatory disorders, cancer, sepsis, and viral infections through immune modulation.

  • 3

    Chemical modifications like periodate oxidation and N-desulfation are key techniques for preparing NAHs, preserving their biological activities.

  • 4

    NAHs interact with proteins such as heparanase and P-selectin, contributing to their anti-inflammatory, anticancer, and vascular protective effects.

  • 5

    This review integrates chemical, mechanistic, and clinical perspectives to advance the development of NAH-based therapies.

Original Source(s)

Non-anticoagulant heparins: glycan-mediated immune modulation and therapeutic applications

  • by Yaner Gu, Qiong Wang, Juan Fang, Jing Chen, Kaiting Hong, Zhanwei Zhang, Syed Shams Ul Hassan, Yin Chen, Xuqian Zhang

  • July 21, 2026

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