Bruton Tyrosine Kinase Inhibitor–Associated Pericardial Events by Agent and Generation - Takeaways - MDSpire
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Pericardial Complications Linked to Bruton Tyrosine Kinase Inhibitors: Comparisons by Agent and Generation

  • By

  • Vinicius De Sousa Barzon Serra

  • Ramzi Ibrahim

  • Julia Zanco

  • Amjed Al Abdel

  • Amal Youssef

  • Dina Hauptschein

  • Karam Albdour

  • Luke Dreher

  • Hema Narayanasamy

  • Kwan Lee

  • Balaji Tamarappoo

  • J. Christopher Ray

  • Talal Hilal

  • Luis R. Scott

  • Joerg Herrmann

  • Chadi Ayoub

  • Reza Arsanjani

  • November 9, 2026

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  • 1

    This retrospective Mayo Clinic study included 575 adults who initiated a BTK inhibitor from 2012 through 2025 and had no documented pericardial disease at baseline.

  • 2

    During a median follow-up of 2.2 years, 34 patients (5.9%) developed pericardial effusion or cardiac tamponade, at 1.9 events per 100 person-years.

  • 3

    Cardiac tamponade occurred in 3 patients, all receiving ibrutinib, and pericarditis was reported in 7 patients.

  • 4

    Adjusted analyses found no association between newer-generation BTK inhibitors and the primary outcome or between individual agents and the outcome compared with ibrutinib.

  • 5

    Shorter follow-up for newer agents, clinically driven event detection, and few events limited comparisons, and the study could not establish whether risk varied by agent or generation.

Original Source(s)

Bruton Tyrosine Kinase Inhibitor–Associated Pericardial Events by Agent and Generation

  • by Vinicius De Sousa Barzon Serra, Ramzi Ibrahim, Julia Zanco, Amjed Al Abdel, Amal Youssef, Dina Hauptschein, Karam Albdour, Luke Dreher, Hema Narayanasamy, Kwan Lee, Balaji Tamarappoo, J. Christopher Ray, Talal Hilal, Luis R. Scott, Joerg Herrmann, Chadi Ayoub, Reza Arsanjani

  • November 9, 2026

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