The Role of Hemoglobin and Anemia in Preventing Dementia—Revisiting a Well-Known Protein

1

Anemia affects 25% of the global population and is linked to a 66% increased risk of developing dementia over time.
2

The Swedish National study on Aging and Care in Kungsholmen provides robust data supporting the association between anemia and dementia.
3

Low hemoglobin levels correlate with higher dementia risk, particularly below a threshold of approximately 14 g/dL.
4

Anemia interacts with plasma biomarkers of neurodegenerative disease, increasing dementia risk 3- to 4-fold when both are present.
5

Further studies are needed to explore the mechanisms linking anemia, hemoglobin levels, and dementia, particularly regarding iron and B vitamin metabolism.