A systematic review and meta-analysis of the systemic immune-inflammation index (SII) in rheumatic diseases - Takeaways - MDSpire

A systematic review and meta-analysis of the systemic immune-inflammation index (SII) in rheumatic diseases

  • By

  • Arduino A. Mangoni

  • Angelo Zinellu

  • July 13, 2026

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  • 1

    The systemic immune-inflammation index (SII) is calculated as (neutrophil count x platelet count)/lymphocyte count.

  • 2

    Patients with rheumatic diseases (RDs) exhibited significantly higher SII values compared to healthy controls in a meta-analysis of 52 studies.

  • 3

    The pooled standardized mean difference for SII in RDs was 0.83, indicating a strong association with very low certainty of evidence.

  • 4

    Subgroup analysis revealed significant SII differences across most RD categories, except for fibromyalgia and connective tissue disease.

  • 5

    Further research is needed to define clinically useful SII thresholds and assess its diagnostic or prognostic performance in RDs.

Original Source(s)

A systematic review and meta-analysis of the systemic immune-inflammation index (SII) in rheumatic diseases

  • by Arduino A. Mangoni, Angelo Zinellu

  • July 13, 2026

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