Crosstalk between liver sinusoidal endothelial cells and hepatocytes via IL-1α–IL1R1 axis exacerbates ischaemia/reperfusion injury in aged livers - Takeaways - MDSpire
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Interaction between liver sinusoidal endothelial cells and hepatocytes through the IL-1α–IL1R1 pathway worsens ischaemia/reperfusion injury in older livers

  • By

  • Yasong Liu

  • Tingting Wang

  • Feng Zhang

  • Xuying Liu

  • Zhongying Hu

  • Jiebin Zhang

  • Haitian Chen

  • Jiaqi Xiao

  • Qiang You

  • Zhengqi Wu

  • Jia Yao

  • Yingcai Zhang

  • Shuhong Yi

  • Hua Li

  • Qi Zhang

  • Yang Yang

  • Rong Li

  • Jun Zheng

  • August 1, 2026

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  • 1

    Aged livers show increased susceptibility to ischaemia-reperfusion injury (IRI) due to diminished tolerance.

  • 2

    Liver sinusoidal endothelial cells (LSECs) exhibit elevated IL-1α expression, worsening IRI in aged livers.

  • 3

    A positive feedback loop involving TNF-α enhances MEIS2 activity in LSECs, promoting inflammation during IRI.

  • 4

    Therapeutic blockade of the IL-1α–IL1R1 pathway significantly reduces hepatic injury in aged rat models.

  • 5

    Identifying IL-1α–IL1R1 crosstalk provides a novel therapeutic target for improving outcomes in elderly patients.

Original Source(s)

Crosstalk between liver sinusoidal endothelial cells and hepatocytes via IL-1α–IL1R1 axis exacerbates ischaemia/reperfusion injury in aged livers

  • by Yasong Liu, Tingting Wang, Feng Zhang, Xuying Liu, Zhongying Hu, Jiebin Zhang, Haitian Chen, Jiaqi Xiao, Qiang You, Zhengqi Wu, Jia Yao, Yingcai Zhang, Shuhong Yi, Hua Li, Qi Zhang, Yang Yang, Rong Li, Jun Zheng

  • August 1, 2026

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