Unveiling a J-shaped association between the triglyceride-glucose index and in-hospital major adverse cardiovascular events in patients with acute myocardial infarction: a retrospective cohort study of 1,065 patients - Takeaways - MDSpire

Unveiling a J-shaped association between the triglyceride-glucose index and in-hospital major adverse cardiovascular events in patients with acute myocardial infarction: a retrospective cohort study of 1,065 patients

  • By

  • Yikang Xu

  • Jia Liu

  • Yang Yang

  • Limin Liu

  • Jingru Ma

  • Xiren Meng

  • Shuochao Zhao

  • Yaxin Wang

  • Lisheng Xu

  • Stephen E. Greenwald

  • July 7, 2026

  • 0 min

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  • 1

    The study analyzed 1,065 acute myocardial infarction patients to explore the relationship between the triglyceride-glucose index and in-hospital major adverse cardiovascular events.

  • 2

    Patients were categorized into three groups based on the TyG index tertiles, revealing significant differences in clinical characteristics among the groups.

  • 3

    The overall incidence of in-hospital major adverse cardiovascular events was 21.13%, with the medium TyG group showing the highest incidence at 26.04%.

  • 4

    A J-shaped relationship was identified between the TyG index and MACE risk, with an inflection point at TyG = 9.05, indicating increased risk beyond this threshold.

  • 5

    The core model incorporating TyG index stratification demonstrated improved predictive performance for MACE, highlighting the importance of nonlinear effects in risk assessment.

Original Source(s)

Unveiling a J-shaped association between the triglyceride-glucose index and in-hospital major adverse cardiovascular events in patients with acute myocardial infarction: a retrospective cohort study of 1,065 patients

  • by Yikang Xu, Jia Liu, Yang Yang, Limin Liu, Jingru Ma, Xiren Meng, Shuochao Zhao, Yaxin Wang, Lisheng Xu, Stephen E. Greenwald

  • July 7, 2026

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