ROHHAD syndrome: an interdisciplinary perspective - Takeaways - MDSpire

ROHHAD syndrome: an interdisciplinary perspective

  • By

  • Anna Mercante

  • Annalisa Salerno

  • Anna Marinetto

  • Anna Santini

  • Benedetta Tascini

  • Alessia Raffagnato

  • Valentina De Tommasi

  • Antuan Divisic

  • Franca Benini

  • June 3, 2026

  • 0 min

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  • 1

    ROHHAD syndrome is a rare, complex disorder characterized by rapid-onset obesity, hypothalamic dysfunction, hypoventilation, and autonomic dysregulation.

  • 2

    The study analyzed six clinically confirmed ROHHAD cases over 13 years, revealing a median age of onset at 3.3 years and a diagnostic delay of 1.6 years.

  • 3

    Central hypoventilation was a significant clinical challenge, with most patients requiring tracheostomy and long-term invasive ventilation.

  • 4

    Endocrine and neurodevelopmental issues were common, with many patients experiencing severe behavioral dysregulation affecting treatment adherence.

  • 5

    The findings emphasize the need for interdisciplinary care and proactive management to improve outcomes for patients with ROHHAD syndrome.

Original Source(s)

ROHHAD syndrome: an interdisciplinary perspective

  • by Anna Mercante, Annalisa Salerno, Anna Marinetto, Anna Santini, Benedetta Tascini, Alessia Raffagnato, Valentina De Tommasi, Antuan Divisic, Franca Benini

  • June 3, 2026

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