HSP90 inhibitor NVP-BEP800 affects stability of SRC kinases and growth of T-cell and B-cell acute lymphoblastic leukemias - Takeaways - MDSpire

HSP90 inhibitor NVP-BEP800 affects stability of SRC kinases and growth of T-cell and B-cell acute lymphoblastic leukemias

  • By

  • Rony Mshaik

  • John Simonet

  • Aleksandra Georgievski

  • Layla Jamal

  • Shaliha Bechoua

  • Paola Ballerini

  • Pierre-Simon Bellaye

  • Zandile Mlamla

  • Jean-Paul Pais de Barros

  • Audrey Geissler

  • Pierre-Jean Francin

  • François Girodon

  • Carmen Garrido

  • Ronan Quéré

  • March 18, 2021

  • 0 min

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  • 1

    Acute lymphoblastic leukemia (ALL) is a heterogeneous cancer affecting T- or B-lymphocyte precursors, predominantly in children.

  • 2

    HSP90 inhibitors, including NVP-BEP800, have shown potential in treating T-ALL and B-ALL by destabilizing SRC kinases.

  • 3

    NVP-BEP800 reduced the viability of primary T-ALL and B-ALL cells in vitro and inhibited leukemia cell proliferation in xenograft models.

  • 4

    High HSP90 expression correlates with poor survival rates in ALL patients, indicating its potential as a therapeutic target.

  • 5

    The study emphasizes the need for new therapies to improve remission maintenance and survival in ALL patients.

Original Source(s)

HSP90 inhibitor NVP-BEP800 affects stability of SRC kinases and growth of T-cell and B-cell acute lymphoblastic leukemias

  • by Rony Mshaik, John Simonet, Aleksandra Georgievski, Layla Jamal, Shaliha Bechoua, Paola Ballerini, Pierre-Simon Bellaye, Zandile Mlamla, Jean-Paul Pais de Barros, Audrey Geissler, Pierre-Jean Francin, François Girodon, Carmen Garrido, Ronan Quéré

  • March 18, 2021

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